Blood Is a Living Organ. Oxygen Delivery Is a Function.
Different species. The same biological need: oxygen. BHOC focuses on supporting oxygen delivery at the tissue level within Precision Oxygen Therapeutics.
Our research vision
One Oxygen.One Biology.One BHOC System.For Every Species.
Wherever Life Is at Risk or Needs Support to Heal.
Blood is a living system with many functions
Blood is a living connective tissue. We view it as a circulating organ because its cells and plasma work together in transport, regulation and protection. Oxygen delivery is one vital function within that larger system.
Red cells, platelets, plasma proteins and immune cells have different roles. Supporting oxygen transport is therefore a defined therapeutic task within veterinary care. This functional distinction shapes our approach to BHOC.[1]
Animal blood transfusion: identify the function needed
A 2009 Veterinary Practice News report described the move towards blood components selected for the patient's needs. Its practical lesson provides a useful starting point: identify the required function and choose the corresponding support.
For dogs, cats and horses, donor blood, compatibility testing and blood-bank cooperation remain central parts of transfusion care. Our research question is how oxygen-carrying support can be added and evaluated alongside that care.[2]
Oxyglobin: a veterinary oxygen-carrying precedent
Oxyglobin, hemoglobin glutamer-200 (bovine), is a dog-specific veterinary precedent for hemoglobin-based oxygen-carrying support. The European regulatory record identifies the product and its target species as dogs. Its history helps distinguish oxygen-carrying support from the wider functions of donor blood.
This experience informs research design. BHOC is a separate development programme with its own formulation, characterization and validation.[3][4]
BHOC: supporting the function throughout care
BHOC, Biological Hemoglobin Oxygen Carrier, is being developed within Precision Oxygen Therapeutics to support sustained, controlled oxygen delivery adapted to local tissue demand, whether donor blood is available or a transfusion is underway.
Our aim is physiologically responsive oxygen unloading: greater release where local oxygen tension is low, and less where oxygen is sufficient. Research priorities also include oxygen-dependent immune function, iron recovery and endogenous erythropoiesis, wound healing and rehabilitation.
For Every Species expresses our research vision. Each proposed veterinary application will be assessed through product- and species-specific studies.[5][6]
We invite veterinary blood banks, clinicians and research teams to help define the functional measurements and studies that can advance this work. The question is what function the patient needs, and how we can verify that it is being supported.